To minimize systemic absorption when administering an ophthalmic medication, which action should a nurse take?

To minimize systemic absorption when administering ophthalmic medications, applying pressure to the inner canthus after the drops is the most effective action. This technique reduces the drainage of the medication into the systemic circulation through the nasolacrimal duct. By occluding the puncta (small openings in the inner corner of the eyelids), the medication remains in contact with the eye surface longer, enhancing its therapeutic effect while also limiting absorption into the systemic circulation.

Other options do not effectively address the goal of minimizing systemic absorption. For instance, instilling drops while the client is standing does not influence the absorption process and might lead to improper positioning, making it more difficult to administer the medication accurately. Waiting five minutes before instilling drops in the other eye is relevant for ensuring efficacy in multi-eye drop scenarios, but it does not directly reduce systemic absorption of the first drop. Rinsing the eye after instillation can actually wash away the medication, negating its intended therapeutic effect. Therefore, applying pressure to the inner canthus remains the optimal action to achieve the primary goal of reduced systemic absorption.